Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Foxa2  forkhead box A2   (Synonyms: Hnf3b, Hnf-3b, HNF3beta, HNF3-beta, Tcf3b, Tcf-3b)
Results	Reference
1	J:127541 Andersson O, Bertolino P, Ibanez CF, Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development. Dev Biol. 2007 Nov 15;311(2):500-11
1*	J:16244 Ang SL, Wierda A, Wong D, Stevens KA, Cascio S, Rossant J, Zaret KS, The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins. Development. 1993 Dec;119(4):1301-15
1	J:131055 Arnold SJ, Hofmann UK, Bikoff EK, Robertson EJ, Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse. Development. 2008 Feb;135(3):501-11
1	J:76369 Auman HJ, Nottoli T, Lakiza O, Winger Q, Donaldson S, Williams T, Transcription factor AP-2gamma is essential in the extra-embryonic lineages for early postimplantation development. Development. 2002 Jun;129(11):2733-47
1	J:81247 Beck S, Le Good JA, Guzman M, Ben Haim N, Roy K, Beermann F, Constam DB, Extraembryonic proteases regulate Nodal signalling during gastrulation. Nat Cell Biol. 2002 Dec;4(12):981-5
1	J:234992 Benz BA, Nandadasa S, Takeuchi M, Grady RC, Takeuchi H, LoPilato RK, Kakuda S, Somerville RP, Apte SS, Haltiwanger RS, Holdener BC, Genetic and biochemical evidence that gastrulation defects in Pofut2 mutants result from defects in ADAMTS9 secretion. Dev Biol. 2016 Aug 1;416(1):111-22
1	J:61931 Beppu H, Kawabata M, Hamamoto T, Chytil A, Minowa O, Noda T, Miyazono K, BMP type II receptor is required for gastrulation and early development of mouse embryos. Dev Biol. 2000 May 1;221(1):249-58
1	J:254597 Bhargava S, Cox B, Polydorou C, Gresakova V, Korinek V, Strnad H, Sedlacek R, Epp TA, Chawengsaksophak K, The epigenetic modifier Fam208a is required to maintain epiblast cell fitness. Sci Rep. 2017 Aug 24;7(1):9322
1*	J:302463 Buers I, Pennekamp P, Nitschke Y, Lowe C, Skryabin BV, Rutsch F, Lmbrd1 expression is essential for the initiation of gastrulation. J Cell Mol Med. 2016 Aug;20(8):1523-33
1*	J:79514 Burke Z, Oliver G, Prox1 is an early specific marker for the developing liver and pancreas in the mammalian foregut endoderm. Mech Dev. 2002 Oct;118(1-2):147
1*	J:178972 Cajal M, Lawson KA, Hill B, Moreau A, Rao J, Ross A, Collignon J, Camus A, Clonal and molecular analysis of the prospective anterior neural boundary in the mouse embryo. Development. 2012 Jan;139(2):423-36
1	J:110605 Camus A, Perea-Gomez A, Moreau A, Collignon J, Absence of Nodal signaling promotes precocious neural differentiation in the mouse embryo. Dev Biol. 2006 Jul 15;295(2):743-55
1	J:327432 Chen T, Alcorn H, Devbhandari S, Remus D, Lacy E, Huangfu D, Anderson KV, A hypomorphic mutation in Pold1 disrupts the coordination of embryo size expansion and morphogenesis during gastrulation. Biol Open. 2022 Aug 15;11(8):bio059307
1	J:81582 Chen W, Liang Y, Deng W, Shimizu K, Ashique AM, Li E, Li YP, The zinc-finger protein CNBP is required for forebrain formation in the mouse. Development. 2003 Apr;130(7):1367-79
1	J:92066 Chu GC, Dunn NR, Anderson DC, Oxburgh L, Robertson EJ, Differential requirements for Smad4 in TGFbeta-dependent patterning of the early mouse embryo. Development. 2004 Aug;131(15):3501-12
1	J:186907 D'Andrea D, Liguori GL, Le Good JA, Lonardo E, Andersson O, Constam DB, Persico MG, Minchiotti G, Cripto promotes A-P axis specification independently of its stimulatory effect on Nodal autoinduction. J Cell Biol. 2008 Feb 11;180(3):597-605
1	J:239417 Dai HQ, Wang BA, Yang L, Chen JJ, Zhu GC, Sun ML, Ge H, Wang R, Chapman DL, Tang F, Sun X, Xu GL, TET-mediated DNA demethylation controls gastrulation by regulating Lefty-Nodal signalling. Nature. 2016 Oct 27;538(7626):528-532
1*	J:56091 Davidson BP, Kinder SJ, Steiner K, Schoenwolf GC, Tam PP, Impact of node ablation on the morphogenesis of the body axis and the lateral asymmetry of the mouse embryo during early organogenesis. Dev Biol. 1999 Jul 1;211(1):11-26
1	J:85554 del Barco Barrantes I, Davidson G, Grone HJ, Westphal H, Niehrs C, Dkk1 and noggin cooperate in mammalian head induction. Genes Dev. 2003 Sep 15;17(18):2239-44
1*	J:89944 DeYoung RA, Baker JC, Cado D, Winoto A, The orphan steroid receptor Nur77 family member Nor-1 is essential for early mouse embryogenesis. J Biol Chem. 2003 Nov 21;278(47):47104-9
1	J:50343 Ding J, Yang L, Yan YT, Chen A, Desai N, Wynshaw-Boris A, Shen MM, Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo [see comments]. Nature. 1998 Oct 15;395(6703):702-7
1*	J:165751 Du J, Takeuchi H, Leonhard-Melief C, Shroyer KR, Dlugosz M, Haltiwanger RS, Holdener BC, O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Dev Biol. 2010 Oct 1;346(1):25-38
1	J:89189 Dunn NR, Vincent SD, Oxburgh L, Robertson EJ, Bikoff EK, Combinatorial activities of Smad2 and Smad3 regulate mesoderm formation and patterning in the mouse embryo. Development. 2004 Apr;131(8):1717-28
1*	J:27183 Duyao MP, Auerbach AB, Ryan A, Persichetti F, Barnes GT, McNeil SM, Ge P, Vonsattel JP, Gusella JF, Joyner AL, MacDonald ME, Inactivation of the mouse Huntington's disease gene homolog Hdh. Science. 1995 Jul 21;269(5222):407-10
1*	J:16386 Echelard Y, Epstein DJ, St-Jacques B, Shen L, Mohler J, McMahon JA, McMahon AP, Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell. 1993 Dec 31;75(7):1417-30
1	J:154368 Farkas DR, Chapman DL, Kinked tail mutation results in notochord defects in heterozygotes and distal visceral endoderm defects in homozygotes. Dev Dyn. 2009 Oct 29;238(12):3237-3247
1*	J:23134 Faust C, Schumacher A, Holdener B, Magnuson T, The eed mutation disrupts anterior mesoderm production in mice. Development. 1995 Feb;121(2):273-85
1*	J:131814 Fukusumi Y, Naruse C, Asano M, Wtap is required for differentiation of endoderm and mesoderm in the mouse embryo. Dev Dyn. 2008 Mar;237(3):618-29
1	J:135128 Guo Q, Li JY, Distinct functions of the major Fgf8 spliceform, Fgf8b, before and during mouse gastrulation. Development. 2007 Jun;134(12):2251-60
1*	J:217681 Halstead AM, Wright CV, Disrupting Foxh1-Groucho interaction reveals robustness of nodal-based embryonic patterning. Mech Dev. 2015 May;136:155-65
1	J:193728 Hong M, Krauss RS, Cdon mutation and fetal ethanol exposure synergize to produce midline signaling defects and holoprosencephaly spectrum disorders in mice. PLoS Genet. 2012;8(10):e1002999
1	J:69594 Hoodless PA, Pye M, Chazaud C, Labbe E, Attisano L, Rossant J, Wrana JL, FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse. Genes Dev. 2001 May 15;15(10):1257-71
1*	J:122556 Inoue T, Ota M, Mikoshiba K, Aruga J, Zic2 and Zic3 synergistically control neurulation and segmentation of paraxial mesoderm in mouse embryo. Dev Biol. 2007 Jun 15;306(2):669-84
1	J:80667 Iratni R, Yan YT, Chen C, Ding J, Zhang Y, Price SM, Reinberg D, Shen MM, Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1. Science. 2002 Dec 6;298(5600):1996-9
1	J:55887 Izraeli S, Lowe LA, Bertness VL, Good DJ, Dorward DW, Kirsch IR, Kuehn MR, The SIL gene is required for mouse embryonic axial development and left-right specification. Nature. 1999 Jun 17;399(6737):691-4
1	J:91055 Kelly OG, Pinson KI, Skarnes WC, The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice. Development. 2004 Jun;131(12):2803-15
1*	J:64866 Kimura C, Yoshinaga K, Tian E, Suzuki M, Aizawa S, Matsuo I, Visceral endoderm mediates forebrain development by suppressing posteriorizing signals. Dev Biol. 2000 Sep 15;225(2):304-21
1	J:324183 Kimura-Yoshida C, Mochida K, Kanno SI, Matsuo I, USP39 is essential for mammalian epithelial morphogenesis through upregulation of planar cell polarity components. Commun Biol. 2022 Apr 19;5(1):378
1*	J:71995 Kinder SJ, Tsang TE, Wakamiya M, Sasaki H, Behringer RR, Nagy A, Tam PP, The organizer of the mouse gastrula is composed of a dynamic population of progenitor cells for the axial mesoderm. Development. 2001 Sep;128(18):3623-34
1	J:210110 Komatsu Y, Kishigami S, Mishina Y, In situ hybridization methods for mouse whole mounts and tissue sections with and without additional beta-galactosidase staining. Methods Mol Biol. 2014;1092:1-15
1*	J:117234 Komatsu Y, Scott G, Nagy A, Kaartinen V, Mishina Y, BMP type I receptor ALK2 is essential for proper patterning at late gastrulation during mouse embryogenesis. Dev Dyn. 2007 Feb;236(2):512-7
1	J:244157 Lange L, Marks M, Liu J, Wittler L, Bauer H, Piehl S, Blass G, Timmermann B, Herrmann BG, Patterning and gastrulation defects caused by the tw18 lethal are due to loss of Ppp2r1a. Biol Open. 2017 Jun 15;6(6):752-764
1	J:236825 Langer D, Martianov I, Alpern D, Rhinn M, Keime C, Dolle P, Mengus G, Davidson I, Essential role of the TFIID subunit TAF4 in murine embryogenesis and embryonic stem cell differentiation. Nat Commun. 2016 Mar 30;7:11063
1	J:136396 Liao X, Collins MD, All-trans retinoic acid-induced ectopic limb and caudal structures: murine strain sensitivities and pathogenesis. Dev Dyn. 2008 Jun;237(6):1553-64
1	J:132584 Liguori GL, Borges AC, D'Andrea D, Liguoro A, Goncalves L, Salgueiro AM, Persico MG, Belo JA, Cripto-independent Nodal signaling promotes positioning of the A-P axis in the early mouse embryo. Dev Biol. 2008 Mar 15;315(2):280-9
1*	J:93140 Lu CC, Robertson EJ, Multiple roles for Nodal in the epiblast of the mouse embryo in the establishment of anterior-posterior patterning. Dev Biol. 2004 Sep 1;273(1):149-59
1	J:178623 Madabhushi M, Lacy E, Anterior visceral endoderm directs ventral morphogenesis and placement of head and heart via BMP2 expression. Dev Cell. 2011 Nov 15;21(5):907-19
1	J:195910 Maier JA, Lo Y, Harfe BD, Foxa1 and Foxa2 are required for formation of the intervertebral discs. PLoS One. 2013;8(1):e55528
1	J:62027 Martinez Barbera JP, Clements M, Thomas P, Rodriguez T, Meloy D, Kioussis D, Beddington RS, The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation. Development. 2000 Jun;127(11):2433-45
1	J:176435 Mesnard D, Donnison M, Fuerer C, Pfeffer PL, Constam DB, The microenvironment patterns the pluripotent mouse epiblast through paracrine Furin and Pace4 proteolytic activities. Genes Dev. 2011 Sep 1;25(17):1871-80
1	J:173526 Migeotte I, Grego-Bessa J, Anderson KV, Rac1 mediates morphogenetic responses to intercellular signals in the gastrulating mouse embryo. Development. 2011 Jul;138(14):3011-20
1	J:119568 Miura S, Davis S, Klingensmith J, Mishina Y, BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites. Development. 2006 Oct;133(19):3767-75
1*	J:86144 Miura S, Mishina Y, Whole-embryo culture of E5.5 mouse embryos: development to the gastrulation stage. Genesis. 2003 Sep;37(1):38-43
1	J:285408 Mzoughi S, Di Tullio F, Low DHP, Motofeanu CM, Ong SLM, Wollmann H, Wun CM, Kruszka P, Muenke M, Hildebrandt F, Dunn NR, Messerschmidt DM, Guccione E, PRDM15 loss of function links NOTCH and WNT/PCP signaling to patterning defects in holoprosencephaly. Sci Adv. 2020 Jan;6(2):eaax9852
1*	J:77125 Norris DP, Brennan J, Bikoff EK, Robertson EJ, The Foxh1-dependent autoregulatory enhancer controls the level of Nodal signals in the mouse embryo. Development. 2002 Jul;129(14):3455-68
1	J:286691 Perea-Gomez A, Cases O, Lelievre V, Pulina MV, Collignon J, Hadjantonakis AK, Kozyraki R, Loss of Cubilin, the intrinsic factor-vitamin B12 receptor, impairs visceral endoderm endocytosis and endodermal patterning in the mouse. Sci Rep. 2019 Jul 15;9(1):10168
1	J:81339 Perea-Gomez A, Vella FD, Shawlot W, Oulad-Abdelghani M, Chazaud C, Meno C, Pfister V, Chen L, Robertson E, Hamada H, Behringer RR, Ang SL, Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks. Dev Cell. 2002 Nov;3(5):745-56
1	J:205747 Polydorou C, Georgiades P, Ets2-dependent trophoblast signalling is required for gastrulation progression after primitive streak initiation. Nat Commun. 2013;4:1658
1	J:321351 Pulina MV, Sahr KE, Nowotschin S, Baron MH, Hadjantonakis AK, A conditional mutant allele for analysis of Mixl1 function in the mouse. Genesis. 2014 May;52(5):417-23
1	J:119028 Rakeman AS, Anderson KV, Axis specification and morphogenesis in the mouse embryo require Nap1, a regulator of WAVE-mediated actin branching. Development. 2006 Aug;133(16):3075-83
1	J:75491 Roberts C, Sutherland HF, Farmer H, Kimber W, Halford S, Carey A, Brickman JM, Wynshaw-Boris A, Scambler PJ, Targeted mutagenesis of the Hira gene results in gastrulation defects and patterning abnormalities of mesoendodermal derivatives prior to early embryonic lethality. Mol Cell Biol. 2002 Apr;22(7):2318-28
1*	J:11921 Sasaki H, Hogan BL, Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. Development. 1993 May;118(1):47-59
1	J:341093 Schule KM, Weckerle J, Probst S, Wehmeyer AE, Zissel L, Schroder CM, Tekman M, Kim GJ, Schlagl IM, Sagar, Arnold SJ, Eomes restricts Brachyury functions at the onset of mouse gastrulation. Dev Cell. 2023 Sep 25;58(18):1627-1642.e7
1*	J:244313 Simon CS, Downes DJ, Gosden ME, Telenius J, Higgs DR, Hughes JR, Costello I, Bikoff EK, Robertson EJ, Functional characterisation of cis-regulatory elements governing dynamic Eomes expression in the early mouse embryo. Development. 2017 Apr 01;144(7):1249-1260
1*	J:57262 Song J, Oh SP, Schrewe H, Nomura M, Lei H, Okano M, Gridley T, Li E, The type II activin receptors are essential for egg cylinder growth, gastrulation, and rostral head development in mice. Dev Biol. 1999 Sep 1;213(1):157-69
1	J:239945 Souilhol C, Perea-Gomez A, Camus A, Beck-Cormier S, Vandormael-Pournin S, Escande M, Collignon J, Cohen-Tannoudji M, NOTCH activation interferes with cell fate specification in the gastrulating mouse embryo. Development. 2015 Nov 01;142(21):3649-60
1	J:163670 Spruce T, Pernaute B, Di-Gregorio A, Cobb BS, Merkenschlager M, Manzanares M, Rodriguez TA, An early developmental role for miRNAs in the maintenance of extraembryonic stem cells in the mouse embryo. Dev Cell. 2010 Aug 17;19(2):207-19
1	J:171680 Stuckey DW, Di Gregorio A, Clements M, Rodriguez TA, Correct patterning of the primitive streak requires the anterior visceral endoderm. PLoS One. 2011;6(3):e17620
1*	J:51989 Suda Y, Nakabayashi J, Matsuo I, Aizawa S, Functional equivalency between Otx2 and Otx1 in development of the rostral head. Development. 1999 Feb;126(4):743-57
1	J:84300 Vincent SD, Dunn NR, Hayashi S, Norris DP, Robertson EJ, Cell fate decisions within the mouse organizer are governed by graded Nodal signals. Genes Dev. 2003 Jul 1;17(13):1646-62
1	J:106144 Ware SM, Harutyunyan KG, Belmont JW, Zic3 is critical for early embryonic patterning during gastrulation. Dev Dyn. 2006 Mar;235(3):776-85
1	J:138862 Warr N, Powles-Glover N, Chappell A, Robson J, Norris D, Arkell RM, Zic2-associated holoprosencephaly is caused by a transient defect in the organizer region during gastrulation. Hum Mol Genet. 2008 Oct 1;17(19):2986-96
1	J:185554 Wu CI, Hoffman JA, Shy BR, Ford EM, Fuchs E, Nguyen H, Merrill BJ, Function of Wnt/beta-catenin in counteracting Tcf3 repression through the Tcf3-beta-catenin interaction. Development. 2012 Jun;139(12):2118-29
1	J:69593 Yamamoto M, Meno C, Sakai Y, Shiratori H, Mochida K, Ikawa Y, Saijoh Y, Hamada H, The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse. Genes Dev. 2001 May 15;15(10):1242-56
1	J:161524 Yang YP, Anderson RM, Klingensmith J, BMP antagonism protects Nodal signaling in the gastrula to promote the tissue interactions underlying mammalian forebrain and craniofacial patterning. Hum Mol Genet. 2010 Aug 1;19(15):3030-42
1	J:163880 Zhou X, Anderson KV, Development of head organizer of the mouse embryo depends on a high level of mitochondrial metabolism. Dev Biol. 2010 Aug 1;344(1):185-95